You can use this technique to protect a section of flow by only allowing one message to pass through at a time. So you can use the flow context method and don't allow the next message in until you have picked up the context value again.
[{"id":"b6630ded2db7d680","type":"inject","z":"bdd7be38.d3b55","name":"","props":[{"p":"payload"},{"p":"topic","vt":"str"}],"repeat":"","crontab":"","once":false,"onceDelay":0.1,"topic":"","payload":"","payloadType":"date","x":120,"y":1700,"wires":[["ed63ee4225312b40"]]},{"id":"ed63ee4225312b40","type":"delay","z":"bdd7be38.d3b55","name":"Queue","pauseType":"rate","timeout":"5","timeoutUnits":"seconds","rate":"1","nbRateUnits":"1","rateUnits":"minute","randomFirst":"1","randomLast":"5","randomUnits":"seconds","drop":false,"allowrate":false,"outputs":1,"x":290,"y":1700,"wires":[["d4d479e614e82a49","7eb760e019b512dc"]]},{"id":"a82c03c3d34f683c","type":"delay","z":"bdd7be38.d3b55","name":"Some more stuff to do","pauseType":"delay","timeout":"5","timeoutUnits":"seconds","rate":"1","nbRateUnits":"1","rateUnits":"second","randomFirst":"1","randomLast":"5","randomUnits":"seconds","drop":false,"allowrate":false,"outputs":1,"x":780,"y":1700,"wires":[["7c6253e5d34769ac","b23cea1074943d4d"]]},{"id":"2128a855234c1016","type":"link in","z":"bdd7be38.d3b55","name":"link in 1","links":["7c6253e5d34769ac"],"x":75,"y":1780,"wires":[["3a9faf0a95b4a9bb"]]},{"id":"7c6253e5d34769ac","type":"link out","z":"bdd7be38.d3b55","name":"link out 1","mode":"link","links":["2128a855234c1016"],"x":645,"y":1780,"wires":[]},{"id":"b23cea1074943d4d","type":"debug","z":"bdd7be38.d3b55","name":"OUT","active":true,"tosidebar":true,"console":false,"tostatus":false,"complete":"payload","targetType":"msg","statusVal":"","statusType":"auto","x":650,"y":1620,"wires":[]},{"id":"d4d479e614e82a49","type":"debug","z":"bdd7be38.d3b55","name":"IN","active":true,"tosidebar":true,"console":false,"tostatus":false,"complete":"payload","targetType":"msg","statusVal":"","statusType":"auto","x":450,"y":1620,"wires":[]},{"id":"3a9faf0a95b4a9bb","type":"function","z":"bdd7be38.d3b55","name":"Flush","func":"return {flush: 1}","outputs":1,"noerr":0,"initialize":"","finalize":"","libs":[],"x":170,"y":1780,"wires":[["ed63ee4225312b40"]]},{"id":"7eb760e019b512dc","type":"function","z":"bdd7be38.d3b55","name":"Some functions to be performed","func":"\nreturn msg;","outputs":1,"noerr":0,"initialize":"","finalize":"","libs":[],"x":530,"y":1700,"wires":[["a82c03c3d34f683c"]]},{"id":"e35f37deeae94860","type":"comment","z":"bdd7be38.d3b55","name":"Set the queue timeout to larger than you ever expect the process to take","info":"","x":250,"y":1580,"wires":[]}]