Recommendation for remote or wired digital I/O to combine with NR running on Raspberry Pi

I'd like to introduce a netgate hardware to your appication.This netGate named PN6400 can communicate with your sensors via 485/zigbee/WiFi/232 uart and so on.You can control the natGate by Node-red ,and may upload data to cloud such as thingscloud.
The description of netGate is herePN6400