Continuing the discussion from Node-RED on Mac OS Sequoia - local network access issues:
I have the same issue and I am running node-red (via PM2). I have a flow that creates an export of a local mySQL database and FTPs it to a NAS. It stopped working after the Mac Sequoia update and I now just manually copy the export over to the NAS.
I'm going to try this solution (Node-RED on Mac OS Sequoia - local network access issues) in a couple of weeks when I get back home. Hopefully I can then have my automated process back!