Please enclose code, command lines and logs as pre-formatted text for readability.
That file path is missing a \, I think it should be:
\Users\lusuq\.node-red\settings.js
But assuming that the install worked without errors, it may be that you simply need to open a new PowerShell window. Or, at an extreme, you might need to log out and back in again to pick up the updated environment variables.
The settings file is automatically created the first time you run Node-RED. It is initially copied from the Node-RED package. You can manually copy it if you really need to but you shouldn't need to.
Do you have a .node-red directory in c:\Users\lusuq? (you may need to turn on "show hidden files" If it exists, check file permissions. Better still, rename it to .node-red-old and just start node-red.
Microsoft Windows [versão 10.0.19045.5371]
(c) Microsoft Corporation. Todos os direitos reservados.
C:\WINDOWS\system32> node -v
v22.14.0
C:\WINDOWS\system32> node-red
Error loading settings file: \Users\lusuq\.node-red\settings.js
C:\WINDOWS\system32>
Microsoft Windows [versão 10.0.19045.5371]
(c) Microsoft Corporation. Todos os direitos reservados.
C:\Users\lusuq\.node-red>npm list -g
C:\Users\lusuq\AppData\Roaming\npm
+-- node-red@4.0.8
`-- npm@11.1.0
C:\Users\lusuq\.node-red>