@Florian1 Have you tried contacting PIXtend if their instructions do not work? In any case it would be quite impossible to help without seeing what the error message is.
Sorry, I can't help as the product page and documentation is in German. Maybe some German speaking forum member might be able to help. But first you would need to show us what the failure is.
Once Node-RED has started, point a browser at http://172.17.66.87:1880
On Pi Node-RED works better with the Firefox or Chrome browser
Use node-red-stop to stop Node-RED
Use node-red-start to start Node-RED again
Use node-red-log to view the recent log output
Use sudo systemctl enable nodered.service to autostart Node-RED at every boot
Use sudo systemctl disable nodered.service to disable autostart on boot
Starting as a systemd service.
4 Jun 10:36:57 - [info]
Willkommen bei Node-RED!
4 Jun 10:36:57 - [info] Node-RED Version: v1.0.6
4 Jun 10:36:57 - [info] Node.js Version: v10.16.3
4 Jun 10:36:57 - [info] Linux 4.19.66-v7+ arm LE
4 Jun 10:36:58 - [info] Paletten-Nodes werden geladen
4 Jun 10:37:03 - [info] Starting PiXtend V2 -S- Node-RED node!
4 Jun 10:37:03 - [info] Starting PiXtend V2 -L- Node-RED node!
4 Jun 10:37:04 - [red] Uncaught Exception:
4 Jun 10:37:04 - Error: spawn /home/pi/nodered-px2/pixtend2s/../srv/pixtendsrv2 ENOENT
at Process.ChildProcess._handle.onexit (internal/child_process.js:240:19)
at onErrorNT (internal/child_process.js:415:16)
at process._tickCallback (internal/process/next_tick.js:63:19)
nodered.service: Main process exited, code=exited, status=1/FAILURE
nodered.service: Failed with result 'exit-code'.
nodered.service: Service RestartSec=100ms expired, scheduling restart.
nodered.service: Scheduled restart job, restart counter is at 1.
Stopped Node-RED graphical event wiring tool.
Started Node-RED graphical event wiring tool.
4 Jun 10:37:06 - [info]
Willkommen bei Node-RED!
4 Jun 10:37:06 - [info] Node-RED Version: v1.0.6
4 Jun 10:37:06 - [info] Node.js Version: v10.16.3
4 Jun 10:37:06 - [info] Linux 4.19.66-v7+ arm LE
4 Jun 10:37:08 - [info] Paletten-Nodes werden geladen
4 Jun 10:37:11 - [info] Starting PiXtend V2 -S- Node-RED node!
4 Jun 10:37:11 - [info] Starting PiXtend V2 -L- Node-RED node!
4 Jun 10:37:11 - [red] Uncaught Exception:
4 Jun 10:37:11 - Error: spawn /home/pi/nodered-px2/pixtend2s/../srv/pixtendsrv2 ENOENT
at Process.ChildProcess._handle.onexit (internal/child_process.js:240:19)
at onErrorNT (internal/c
I have read through the PDF you posted, did you, as in the instructions start and stop node red once before you did the installation of the PiXtend node? They stressed that it was important.