OK, here is a simple flow which allows a sequence of nodes to be protected so that only one message is allowed in at a time. It uses a Delay node in Rate Limit mode to queue them, but releases them, using the Flush mechanism, as soon as the previous one is complete. Set the timeout in the delay node to a value greater than the maximum time you expect it ever to take. If for some reason the flow locks up (a message fails to indicate completion) then the next message will be released after that time.
Make sure that you trap any errors and feed back to the Flush node when you have handled the error. Also make sure only one message is fed back for each one in, even in the case of errors.
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[Edit] I see this is the same suggestion that @E1cid made.